Atom-economical regioselective Ni-catalyzed hydroborylative cyclization of enynes: development and mechanism

Ruthenium-catalyzed hydrative cyclization of 1,5-enynes.

A ruthenium-catalyzed hydrative cyclization of enynes has been developed. The reaction converts a range of 1,5-enynes bearing terminal alkyne and Michael acceptor moieties into cyclopentanone derivatives. From extensive catalyst screening experiments, a trinuclear ruthenium complex, [Ru3(dppm)3Cl5]PF6, has been identified to be an effective catalyst in mediating the 1,1-difunctionalization of a...

Palladium-catalyzed enantioselective cyclization of silyloxy-1,6-enynes.

Transition-metal-catalyzed cycloisomerization and cyclization reactions of enynes have emerged as powerful methods for the construction of heteroand carbocyclic compounds.1 More recently, enantioselective cycloisomerization of 1,6and 1,7-enynes has been employed in the preparation of enantioenriched 1,4-diene containing structures.2-4 Despite its potential utility, the related enantioselective ...

Ni-catalyzed regioselective three-component coupling of alkyl halides, arylalkynes, or enynes with R-M (M = MgX', ZnX').

A new method for the regioselective three-component cross-coupling of alkyl halides, alkynes, or enynes with organomagnesium or organozinc reagents in the presence of a nickel catalyst and a dppb ligand has been developed.

Ni-Catalyzed Regioselective Three-Component Coupling of Alkyl Halides, Arylalkynes, or Enynes with Ar-M (M = MgX, ZnX)

Cu-catalyzed regioselective carbomagnesiation of dienes and enynes with sec- and tert-alkyl Grignard reagents.

The carbomagnesiation of dienes and enynes with sec- and tert-alkyl Grignard reagents has been achieved by using copper salts as catalysts.